OmniPac PCX-100 Cation-Exchange Column

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Cation-Exchange Column for the Separation of Low-Molecular-Weight Species 

The OmniPac® PCX-100 column is a microporous, solvent-compatible, high-capacity, cation-exchange column designed for the separation of hydrophobic cations, such as amines, drugs, and metabolites.

  • Acid, base, and solvent compatible, pH 0–14

  • Good for organic cations

  • Ideal for the separation of very hydrophobic cations

  • Good for the separation of halogenated cations

The OmniPac PCX-100 column is a specialty cation-exchange column for the separation of low-molecular-weight cations, especially organic analytes. Group 1A and 2A inorganic cations are best separated on the IonPac CS12A column, which is also solvent compatible. The OmniPac PCX-100 column is 100% solvent compatible and should always be run with at least 1% organic solvent in the mobile phase.

The OmniPac PCX-100 is manufactured using a microporous substrate agglomerated with a sulfonated latex bead layer that carries the cation-exchange functionality. The cation-exchange layer is the same as that used in the OmniPac PCX-500 column, and consequently the ion-exchange characteristics of these two columns are identical. The OmniPac PCX-100 column can be used to separate hydrophobic cationic analytes such as amines, anilines, antidepressants, drugs, and metabolites (such as methotrexate and folic acid).

OmniPac PCX-100 Cation-Exchange Column for the Separation of Low-Molecular-Weight Species Specifications
DimensionsOmniPac PCX-100 Analytical Column:
4 × 250 mm
OmniPac PCX-100 Guard Column:
4 × 50 mm
Maximum operating pressure4000 psi (27.9 MPa)
Recommended operating temperatureAmbient
Typical operating conditions1.0 mL/min with at least 1% organic solvent
Recommended flow rate: 1.0 mL/min
Mobile phase compatibility100% compatible with common organic solvents. Recommended eluents: 1% solvent. Acid to maintain weak bases in the cationic form, salt (e.g., Na+ for cation-exchange).
Resin composition8.5-µm-diameter ethylvinylbenzene/divinylbenzene microporous substrate (55% cross-linked) agglomerated with 200-nm MicroBead sulfonic acid-functionalized latex (5% cross-linked).
Anion-exchange capacity120 µeq/column (4 × 250 mm analytical column)
Column constructionPEEK with 10-32 threaded ferrule-style end fittings. All components are nonmetallic.

Isocratic Separation of Aromatic Amines.


Separation of a Mixture of Inorganic Cations, Choline, and Acetylcholine by Two Different Chromatographic Modes.

Analytical Columns
OmniPac PCX-100 Analytical Column (4 x 250 mm)042189
Guard Columns
OmniPac PCX-100 Guard Column (4 x 50 mm)042193